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High-Altitude Hacks: Using DHEA and NO2 to Simulate Acclimation for Trekkers and Trail Runners

High-Altitude Hacks: Using DHEA and NO2 to Simulate Acclimation for Trekkers and Trail Runners

Posted by Medical Research Institute on 14th May 2025

The allure of high-altitude trekking and trail running is undeniable. From the stunning vistas to the exhilarating challenges of navigating rugged terrain, these outdoor pursuits are a true test of endurance. But for many athletes, the biggest obstacle is the lack of oxygen at higher elevations. Whether you're heading to the peaks of the Himalayas, running through the Andes, or tackling the Rockies, your body faces a significant challenge as you climb. Oxygen levels drop, leading to faster fatigue, decreased performance, and the dreaded altitude sickness.

But what if you could simulate the effects of altitude before you even leave your home? With the right supplementation, it's possible to prepare your body for the demands of high-altitude environments. Specifically, DHEA and NO2 can play pivotal roles in helping your body adapt and thrive at elevations where every breath counts.

In this blog, we'll break down how DHEA and NO2 supplementation can support high-altitude training and prepare trekkers and trail runners for their mountain adventures.

What Happens to Your Body at High Altitude?

Before diving into the supplements, let's quickly cover what happens when you ascend to high altitudes. At elevations above 8,000 feet (2,400 meters), the oxygen in the air decreases by about 30%. This leads to a range of physiological changes in the body as it works to adjust to the lack of available oxygen.

  1. Reduced Oxygen Supply: The drop in oxygen leads to lower oxygen saturation in the blood, making it harder for muscles and organs to get the oxygen they need to perform optimally.
  2. Increased Heart Rate: Your heart works harder to circulate oxygen-rich blood throughout the body, which can lead to fatigue more quickly.
  3. Altitude Sickness: Symptoms like headaches, nausea, dizziness, and shortness of breath occur as your body struggles to adjust to the lower oxygen levels.
  4. Decreased Physical Performance: Your body simply cannot generate as much power at high altitudes because there's less oxygen available for energy production in muscles.

But all is not lost. With the right preparation and supplementation, you can help your body acclimate more effectively and push through these physical challenges.

How DHEA Supports High-Altitude Performance

DHEA (Dehydroepiandrosterone) is a naturally occurring hormone produced by the adrenal glands. It plays a crucial role in supporting various bodily functions, including immune response, energy production, and stress management. As you ascend to higher altitudes, your body faces increased physical and mental stress. DHEA supplementation can provide a critical boost during this time by helping your body maintain balance under these stressors.

Benefits of DHEA for High-Altitude Training:

  1. Enhances Oxygen Utilization: Research suggests that DHEA can enhance the body's ability to utilize oxygen, which is vital at high altitudes. By boosting oxygen efficiency in the body, DHEA supplementation can help you preserve energy and perform better in oxygen-deprived environments.
  2. Supports Recovery: High-altitude training can be taxing on the body, leading to muscle breakdown and fatigue. DHEA aids in muscle repair and recovery by supporting the production of other vital hormones like cortisol, which is essential for managing stress and reducing inflammation.
  3. Reduces Stress: At high altitudes, the body is under significant stress due to both physical exertion and low oxygen levels. DHEA can help modulate the stress response, reducing the production of cortisol (the "stress hormone") and improving your body's ability to recover from the physical strain of high-altitude environments.
  4. Balances Energy Production: DHEA supports mitochondrial function, which is responsible for energy production within your cells. This means you can potentially increase your endurance and reduce fatigue during long treks or trail runs at high elevation.

By integrating DHEA into your routine, you can prepare your body for the unique stressors of high-altitude environments, making it more resilient when faced with reduced oxygen levels.

The Power of NO2 for Elevation Adaptation

If DHEA is the hormone that supports your body's internal balance, then NO2 is the powerhouse supplement for improving circulation and oxygen delivery to muscles. NO2, or Nitric Oxide, is a molecule that plays a critical role in vasodilation (the widening of blood vessels), allowing for increased blood flow and oxygen delivery to tissues during intense physical activity.

When you're training at high altitudes, the ability to efficiently deliver oxygen to your muscles is key. NO2 supplementation can help you simulate that effect by enhancing blood flow even at lower oxygen levels, improving your endurance and performance on the trails.

Benefits of NO2 for High-Altitude Performance:

  1. Increased Blood Flow and Oxygen Delivery: NO2 helps dilate blood vessels, improving circulation and allowing more oxygen to reach your muscles. This is particularly beneficial at high altitudes, where oxygen is scarce, as it enables your body to optimize oxygen use for maximum performance.
  2. Improved Endurance and Stamina: By boosting nitric oxide levels, NO2 supplementation can enhance stamina and delay fatigue, allowing you to run longer or trek higher without feeling the debilitating effects of altitude sickness.
  3. Reduced Muscle Fatigue: High altitudes can cause muscle fatigue more quickly due to lower oxygen levels. NO2 helps reduce muscle fatigue by improving blood flow and ensuring that your muscles get the oxygen and nutrients they need to keep pushing forward.
  4. Better Thermoregulation: At high altitudes, your body's thermoregulation can be challenged, making it harder to maintain a comfortable body temperature during physical activity. NO2 helps improve circulation, aiding in heat dissipation and preventing overheating, which is especially crucial during high-altitude training.

By using NO2, you can enhance your body's natural ability to distribute oxygen more effectively, giving you the edge when training in high-altitude conditions.

Combining DHEA and NO2 for Maximum Altitude Adaptation

So, how do you combine DHEA and NO2 for maximum high-altitude performance?

  1. Support Oxygen Utilization with DHEA: DHEA will help your body more efficiently use the available oxygen at higher elevations. This is especially important during prolonged physical exertion, where the body needs to conserve energy and manage stress.
  2. Boost Circulation and Endurance with NO2: NO2 enhances the ability of your body to transport oxygen to muscle tissues, helping you combat fatigue and maintain stamina during long hikes or trail runs in oxygen-deprived environments.
  3. Use Both for a Synergistic Effect: When used together, DHEA and NO2 complement each other by supporting both internal hormone balance and external blood flow. This combination can simulate the physiological responses that your body undergoes when naturally acclimating to high-altitude environments, giving you a performance boost before you even reach the summit.

MRI Performance: Elevate Your High-Altitude Game

At MRI Performance, we understand the demands of high-altitude training and adventure. That's why we offer high-quality, athlete-approved supplements like DHEA and NO2 that are designed to support your performance, recovery, and endurance in the most challenging environments.

Whether you're preparing for an upcoming trek or looking to boost your trail running performance, incorporating DHEA and NO2 into your regimen can give you the edge you need to thrive at altitude.

Take on the Heights with Confidence

High-altitude training isn't easy, but with the right approach and supplementation, it doesn't have to be overwhelming. DHEA and NO2 are two powerful allies that can help you acclimate to the challenges of elevated environments, supporting better oxygen utilization, circulation, and recovery.

By integrating these supplements into your training routine, you're setting yourself up for success on your next mountain adventure.

So, trek higher, run farther, and reach new peaks, with MRI Performance by your side.